Intraoperative electrochemotherapy of colorectal liver metastases

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Intraoperative electrochemotherapy of colorectal liver metastases.

BACKGROUND AND OBJECTIVES Electrochemotherapy is effective in treatment of various cutaneous tumors and could be translated into treatment of deep-seated tumors. With this aim a prospective pilot study was conducted to evaluate feasibility, safety, and efficacy of intraoperative electrochemotherapy in the treatment of colorectal liver metastases. METHODS Electrochemotherapy with bleomycin was...

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Histopathological findings in colorectal liver metastases after electrochemotherapy

Electrochemotherapy of colorectal liver metastases has been proven to be feasible, safe and effective in a phase I/II study. In that study, a specific group of patients underwent two-stage operation, and the detailed histopathological evaluation of the resected tumors is presented here. Regressive changes in electrochemotherapy-treated liver metastases were evaluated after the second operation ...

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Patient variability in intraoperative ultrasonographic characteristics of colorectal liver metastases.

OBJECTIVE To determine the distribution of echogenicity (hypoechoic, isoechoic, or hyperechoic) and predominant intraoperative ultrasonography (IOUS) echogenic appearance of colorectal liver metastasis. The interpatient and intrapatient variability of tumor IOUS echogenicity was assessed. DESIGN Retrospective review of prospectively collected database. SETTING Tertiary cancer center. PATI...

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Intraoperative ultrasonography in detecting and assessment of colorectal liver metastases.

OBJECTIVE to assess the clinical value of intraoperative ultrasonography (IOUS) in detecting and assessment of liver metastatic tumours in colorectal cancer patients. METHODS a study is a retrospective analysis of 388 patients operated on for colorectal carcinoma between 1997 and 2004. In all the patients intraoperative ultrasound was performed. The authors analyzed of sensitivity, specificit...

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Electrochemotherapy of colorectal liver metastases - an observational study of its effects on the electrocardiogram

BACKGROUND Electrochemotherapy (ECT) is a combined treatment in which high voltage electroporation (EP) pulses are used to facilitate the uptake of a chemotherapeutic drug into tumor cells, thus increasing antitumor effectiveness of the drug. The effect of ECT of deep-seated tumors located close to the heart on functioning of the heart has not been previously investigated. In this study, we inv...

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ژورنال

عنوان ژورنال: Journal of Surgical Oncology

سال: 2014

ISSN: 0022-4790,1096-9098

DOI: 10.1002/jso.23625